Vascular Risk Factors and Midlife Cognition

Vascular risk factors and midlife cognition: rethinking the exposure window.

T he connection between cerebrovascular health and cog-nition has been of empirical interest to scientists for over a century. In 1894, Swiss neurologist, Otto Binswanger, described an association between postmortem cerebrovascu-lar changes, including atherosclerosis, and cognitive impairment preceding death in middle-aged and older adults. 1 One-hundred and twenty years later, the field has ev...

Vascular Risk Factors and Midlife Cognition: Re-thinking the Exposure Window Running title: Jefferson; Cumulative vascular risk factors

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.

BACKGROUND Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development of dementia. OBJECTIVE To investigate the relation between midlife body mass index and clustering of vascular risk factors and subsequent dementia and AD. DESIGN ...

Cognition and Vascular Risk Factors: An Epidemiological Study

We conducted an epidemiological approach to identify the negative impact of the vascular risk factors (such as hypertension, diabetes and hypercholesterolemia) over cognition. The interesting aspect of this study was that the survey was conducted in all age groups through a voluntary call (n = 1365; ≥18 years old, both sexes; age 49 ± 15 y, female 75.7%). Thus, we demonstrated that the use of a...

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.

OBJECTIVE To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life. DESIGN Prospective, population based study. SETTING Populations of Kuopio and Joensuu, eastern Finland. PARTICIPANTS Participants were derived from random, population based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1...